|13-甲基-[1,3]二氧杂戊环并[4',5':4,5]苯并[1,2-c][1,3]二氧杂戊环并[4,5-i]菲-13-氯化铵|CsnPharm

CAS No.: 5578-73-4

氯化血根碱 Catalog No. CSN11892

Synonyms: Sanguinarin chloride;Sanguinarium chloride;Pseudochelerythrine chloride

Sanguinarine chloride is a naturally occuring benzophenanthridine alkaloid which can inhibit sodium/potassium-ATPase protein (Na+/K+ ATPase) and cause Epidemic dropsy.

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技术信息

生物活性

描述Sanguinarine chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine (SANG) could induce apoptosis in a dose- and time-dependent manner in UM-SCC-22B head and neck cancer cells. Moreover, SANG-induced apoptosis was associated with the generation of reactive oxygen species (ROS) and activation of JNK and NF-κB signal pathways^[3]. Sanguinarine exhibits antitumor effects in epithelial ovarian cancer cells possible via regulating CASC2-EIF4A3 axis and/or inhibiting NF-κB signaling or PI3K/AKT/mTOR pathway^[4]. Sanguinarine treatment (0.25, 0.5, 1, and 2 µM) of MC3T3-E1 cells significantly increased alkaline phosphatase (ALP) activity and the phoshporalyation of AMPKα, but did not affect cell proliferation. Sanguinarine treatment promoted bone tissue growth in an ovariectomized osteoporosis rat model^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7190 mL
- 13.5950 mL
- 27.1900 mL
- 5 mM
- 0.5438 mL
- 2.7190 mL
- 5.4380 mL
- 10 mM
- 0.2719 mL
- 1.3595 mL
- 2.7190 mL

技术信息

CAS号

5578-73-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H14ClNO4

运输

蓝冰

分子量

367.78

别名

Sanguinarin chloride;Sanguinarium chloride;Pseudochelerythrine chloride;Sanguinarine (chloride);Sangrovit;Pseudochelerythrine;氯化血根碱

溶解度

DMSO	5.0 mg/mL (13.6 mM)
Water	Insoluble
Ethanol	Insoluble

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